Preheat your oven to 400°F (200°C).
In a mixing bowl, combine the breadcrumbs, minced garlic, chopped parsley, dried oregano, red pepper flakes (if using), lemon zest, salt, and pepper. Mix well.
Drizzle the olive oil into the breadcrumb mixture and stir until the crumbs are evenly coated and slightly moist.
In a baking dish, place the peeled and deveined shrimp in a single layer. Squeeze lemon juice over the shrimp, and season with salt and pepper.
Sprinkle the breadcrumb mixture generously over the shrimp, ensuring even coverage.
Bake in the preheated oven for about 15-20 minutes, or until the shrimp are pink and opaque, and the breadcrumbs are golden brown.
Once cooked, remove from the oven, and serve hot with lemon wedges, if desired.