In a mixing bowl, combine the barbecue sauce, grape jelly, Worcestershire sauce, garlic powder, onion powder, and black pepper. Stir until well combined.
Place the Little Smokies in a large skillet over medium heat.
Pour the sauce mixture over the sausages, stirring to coat them evenly.
Bring the mixture to a simmer, then reduce the heat to low.
Cook for about 20 minutes, stirring occasionally, until the sausages are heated through and the sauce is bubbling.
Remove from heat and transfer the Little Smokies to a serving dish.
Serve warm with toothpicks for easy snacking.
For extra flavor, consider adjusting the sweetness or adding a spicy kick with hot sauce or diced jalapeƱos.