Preheat your oven to 350°F (175°C).
In a large mixing bowl, combine the ground chicken, breadcrumbs, Parmesan cheese, chopped onion, chopped bell pepper, minced garlic, ketchup, eggs, dried oregano, salt, black pepper, red pepper flakes (if using), and Worcestershire sauce.
Mix all the ingredients thoroughly until well combined, but do not overmix.
Transfer the mixture into a meatloaf pan or shape it into a loaf and place it on a baking sheet.
Spread a thin layer of ketchup on top of the meatloaf for added flavor and moisture.
Bake in the preheated oven for 60 minutes or until the internal temperature reaches 165°F (74°C).
Remove the meatloaf from the oven and let it rest for about 10 minutes before slicing.
Serve warm with your choice of sides.