Preheat your oven to 350°F (175°C) and grease the loaf pan with non-stick spray or butter.
In a large mixing bowl, combine the pumpkin puree, sugar, vegetable oil, eggs, and vanilla extract. Whisk until the mixture is smooth and well combined.
In another bowl, whisk together the flour, baking soda, baking powder, salt, and spices.
Gradually add the dry ingredients to the pumpkin mixture, stirring gently with a spatula until just combined. Be careful not to overmix.
Pour the batter into the prepared loaf pan, spreading it evenly.
Bake in the preheated oven for 60 minutes, or until a toothpick inserted in the center comes out clean.
Once baked, remove the pumpkin bread from the oven and allow it to cool in the pan for about 10 minutes.
Transfer the pumpkin bread to a wire rack to cool completely.